Treatment of peripheral nerve lesions

Technology description

Peripheral nerve injury affects many people and is due to conditions such as diabetes, hereditary genetic diseases, infectious diseases and inflammatory disorders. The use of tissue engineering and the construction of a regenerative environment can be achieved through a multidisciplinary approach that combines the use of tissue engineering with the construction of an optimized regenerative environment. One of the key aspects is to provide the release of molecules that are able to promote the regeneration of the nerve, and remain stable and active over time.
Neuregulin 1 is a protein essential for the development and regeneration of the nervous system. A specific isoform of this protein was conjugated to iron oxide nanoparticles externally coated with dextran, thus increasing its stability and therefore its activity over time. This delivery system is biocompatible and represents a significant improvement with respect to molecules commercially available.

  • Tissue Engineering
  • Peripheral Nerve regeneration
Key advantages
  • Improved stability and efficacy of the protein
  • Biocompatibility
  • No Toxicity
  • Single injection
  • Possibility to direct it in situ by applying a local magnetic field in the point where its action is required
  • Stefano Geuna
  • Federica Fregnan
  • Giovanna Gambarotta
  • Abraham Shahar 
  • Ofra Ziv-Polate 
Filing date and application number

Filing date: 11/11/2015

Application number: 102015000071499




Università degli Studi di Torino